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Why is Immune Health Important to Your Dog?
According to the U.S. National Canine Cancer Foundation, “one out of every three dogs will get cancer,” it is likely that your dog will have cancer sometime in life. The good news is about half of the cancer types are treatable, if diagnosed early and treated by update treatment programs.
Just like human, the immune system of dog is the key in preventing and combating cancer. Scientists have recognized three primarily protective roles for the immune system in cancer control:
- Eliminating or suppressing viral infections to protect against virus-induced cancers;
- Timely elimination of pathogens and prompt resolution of inflammation to prevent the establishment of an inflammatory environment for cancer growing;
- Immune surveillance, a process to identify and destroy deformed body cells before they become malignancy.
If the immune system of your dog is dysfunction, unable to arrest the deformed body cells to reproduce where possible, a progressively growing cancer will result. Improper immune function also leads to a host of other problems, such as infection, slower healing, organ dysfunction, tissue degeneration, and even early aging.
When your dog’s body functions well and has good immunity, it is easy to keep disease and injury minimal with faster healing and a prolong life as well.
Immunotherapy is a type of cancer treatment designed to boost the body’s natural defenses to fight against cancer, which becomes increasingly important to clinical oncology today. The treatments are provided for different purposes; some boost the overall immune functioning, others help train the immune components to attack cancer cells specifically. Newer types of immunotherapy are coming too, which will definitely change how cancer is treated in the future.
Certain mushrooms such as corioulus versicolor in particular have been found to contain compounds with powerful immune modulation effects. Their protein-bound polysaccharides have positive activities on anti-cancer and immune cell response. In China, medicinal mushrooms have long been used for a wide range of health problems, especially for enhancing and rebuilding the body after major or long-term illnesses.
Our product I’m-Yunity® is made from a proprietary extract of corioulus versicolor, provided by the inventor exclusively, and backup with over 20 years of scientific researches. All the researches about I’m-Yunity® were performed by independent academic institutions in the U.S., Hong Kong and China.
We continued our study in a well-known veterinary research centre in the U.S. A larger scale study has conducted to make sure the pilot results are repeatable with I’m-Yunity® and there is direct benefit from Chinese medicine herbal products.
We value quality research and want to help people better understand about the products they choose to use.
Needed: Dogs Diagnosed with Splenic Hemangiosarcoma
Integrated Chinese Medicine Holdings Ltd. is sponsoring a study at the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania entitled:
Effects of I’m-Yunity vs Standard of Care Chemotherapy (Doxorubicin) Alone or in Combination with I’m-Yunity in Dogs with Splenic Hemangiosarcoma
The study objective:
To assess and compare the efficacy and side effects associated with the administration of I’m-Yunity, doxorubicin, or both in combination to positively impact the lifespan and quality of life in dogs diagnosed with splenic hemangiosarcoma.
To be included in this study the following criteria must be met:
- Your dog must have confirmation of the diagnosis of splenic hemangiosarcoma by biopsy following splenectomy.
- At least 14 days must have passed since the day of surgery.
- Your dog must be stable and not likely to require euthanasia within 4 weeks of starting the study as determined by the investigators.
- You must be able to administer oral medication (multiple pills and capsules) to your dog.
- You must be at least 18 years of age and be able to understand the study requirements.
- You must be able to take your dog to the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania located in Philadelphia for all study visits.
- Your dog cannot have received any treatment for cancer (chemotherapy or I’m-Yunity).
Owners have the choice between I’m-Yunity or traditional chemotherapy for their dog. Half of the dogs in the chemotherapy group will be randomized to receive I’m-Yunity along with chemotherapy. All study visits, diagnostics and study treatments are free of charge.
If you are interested in having your dog participate in this study, please contact the Veterinary Clinical Investigations Center at 215-573-0302 or firstname.lastname@example.org
Coriolus versicolor, also known as Yunzhi, is a precious tonic that belongs to a family of medicinal mushrooms in the Chinese culture. Early in 15th century of China, the famous Compendium of Materia Medica categorized it a supreme herb with health benefits like replenishing essence and qi (vital energy), strengthening tendons and bones, promoting general enhancement and anti-aging. The gentle and invigorating properties of Coriolus versicolor are very suitable to consume regularly for long-term health.
I’m-Yunity® for Dogs is made from a unique proprietary ingredient extracted from Coriolus versicolor, specially for immune balance and vitality of dogs.
Selected herbal source
I’m-Yunity® for Dogs is made from COV-1® strain of Coriolus versicolor. This unique strain was successfully identified and isolated as the optimal strain of Coriolus versicolor among 80 strains collected in China by a reputed fungus expert, Professor Yang Qingyao. He specially cultivated the strain using deep layer cultivation technology with submerged fermentation to provide mycelia as the raw material for our I’m-Yunity® production.
PSP – effective ingredient of Coriolus versicolor
Coriolus versicolor contains bioactive compounds called polysaccharides, which are complex molecules built from many units of sugar. Variation in the compounds occurs if abstracted different parts of the mushroom. Prof. Yang isolated polysaccharide peptide (PSP), a special kind of protein-bound polysaccharides, from the mycelia of COV-1® strain of Coriolus versicolor. Pharmacological and clinical studies have showed that PSP has positive immune modulation effects, and helps improve quality of life.*
Technological breakthrough in PSP extraction
Professor Yang also made a technological breakthrough in the structural elucidation of PSP, that specific types of PSP molecules are isolated from the mycelia of COV-1® strain of Coriolus versicolor. The complex process of insolating effective PSP molecules is one reason why not all products containing PSP may have similar health benefits.
Validated by long-time study and application in human
When PSP first released in the early 80’s, it immediately caught the attention of researchers and customers. Long-time studies along with numerous customer testimonials provided collective evidences that PSP supports immune health, promotes general fitness and improves quality of life. Essence of Mushroom (the Hong Kong packaging of I’m-Yunity®) has been marketed in Hong Kong over 40 years, and registered as a Chinese Proprietary Medicine as well. I’m-Yunity® has also been registered as supplement to sell in Canada, Singapore, Malaysia and Thailand markets.
I’m-Yunity® for Dogs is natural and safe
Unlike other mushroom products, we use exclusively the PSP from the mycelia of COV-1® strain of Coriolus versicolor for the production of I’m-Yunity® for Dogs. It is a pure and single-species herbal supplement that doesn’t rely on other additional ingredients to exert its multiple health benefits. The product is manufactured in the factory with GMP (good manufacturing practices) standard, which further ensures its quality and purity, making your pet getting the most potent PSP active ingredient.
Better quality of life for your beloved pet
Clinical study for dogs with cancer at a well-known veterinary center has showed encouraging results, that I’m-Yunity® as an immune health supplement enhances the quality of life for dogs and benefits general well-being.** Most dog owners may hesitate to opt for chemotherapy for their dogs because of known side effects and high cost. If you wish to boost your dog’s immune fighting abilities, help them get through hard times and achieve a better quality of life, I’m-Yunity® for Dogs is an excellent choice!
I’m-Yunity® for Dogs
A well-researched mushroom supplement for immune balance and vitality of dogs:
100% mushroom extract of COV-1® strain of Coriolus versicolor;
Manufactured in the USA according to cGMP standard;
Complied with heavy metal, pesticide and microbial safety standards;
Clinically tested on efficacy and safety by well-known Universities in Hong Kong, China and USA;
Over 40 years of history on human application;
No report of side effects;
Used vegetarian capsules with natural flavor.
According to the Chinese Materia Medica:
I’m-Yunity® for Dogs
Made from a unique proprietary ingredient extracted from Coriolus versicolor, especially for immune balance and vitality of dogs.
Bottle size: 60 capsules
Dosage: 400 mg per capsule
Based on published clinical study, the best results were achieved when given 100 mg per 1 kg of dog’s body weight per day, which is suggested to split into two equal doses taken with the morning and evening meals.
Your dog should take caps per day
Scientifically Proven Chinese Medicine
I’m-Yunity® for Dogs is a well-researched mushroom supplement with a unique proprietary ingredient – PSP (polysaccharopeptide).
PSP, the active ingredient of I’m-Yunity® has been well researched in independent academic institutions in the United States, Hong Kong and China over the past 20 years. Animal and human clinical trials have shown I’m-Yunity® possesses immune supporting benefits and enhances immune surveillance. ¹,²
A recent clinical trial conducted with dogs taking I’m-Yunity® at a well-known veterinary center in the U.S also gives firmer scientific evidence to I’m-Yunity®’s use in dogs as an immune health supplement to achieve a better quality of life.¹
I’m-Yunity® for Dogs is made from polysaccharide peptide (PSP), a special kind of protein-bound polysaccharides, extracted from the mycelia of COV-1® strain of Coriolus versicolor especially for immune balance and vitality of dogs.
PSP Researches (active ingredient of I’m-Yunity®)
Brown Dorothy Cimino, Reetz Jennifer. Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma. Evidence-based complementary and alternative medicine. eCAM 2012: 384301, (2012).
Liu JX, et al. Phase III clinical trial for Yun Zhi polysaccharide (PSP) capsules. Advanced research in PSP (ed. Yang, Q.Y.), 295-303 (The Hong Kong Association for Health Care Ltd., 1999)
Liu Jx, et al. Phase II clinical trial for PSP capsules. PSP International Symposium (ed. Yang QY and Kwok CY), 183-208 (Fudan University Press, 1993)
Yang JC, et. al Al. The stimulation and inductive effects of Coriolus versicolor polysaccharopeptide (PSP) on interferon. Advanced research in PSP (ed. Yang, Q.Y.), 164-167 (The Hong Kong Association for Health Care Ltd., 1999)
Shiu WCT, et al. A clinical study of PSP on peripheral blood counts during chemotherapy. Phytotherapy research. 6, 217-218 (1992).
Kidd PM. The use of mushroom glucans and proteoglycans in cancer treatment. Alternative Medicine Review. 5, 4-27 (2000).
Tsang KW, et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Respiratory Medicine. 2003 Jun; 97(6):618-24.
Contact Our Distributors Near You
The Chrysler Building, 26th Floor, 405 Lexington Ave, NY 10174, USA
Toll Free: 866 – 932 – 9993
Tel: +1 212 – 868 – 6830
Fax: +1 347 – 230 – 5928
Hong Kong & Other places
Room 209, 2/F, East Ocean Centre, 98 Granville Road, TST East, Hong Kong
Tel: +852 2739 2611
Fax: +852 2721 2451
I’m-Yunity® for Dogs (60 Capsules)
I’m-Yunity® for Dogs is a well-researched mushroom supplement specially for immune balance and vitality of dogs. The product contains a unique proprietary ingredient – PSP (Polysaccharopeptide), extracted from the mycelia of COV-1® strain of Coriolus versicolor. Numerous published studies have shown PSP enhances immune function. Dogs taking I’m-Yunity® enjoy a healthier lifestyle, supported by general fitness and a more robust immune function.
Read more: Why is Immune Health Important to Your Dog?
400mg per capsule
Coriolus versicolor (mycelia) with standardized polysaccharopeptide (PSP)
Dogs need to boost their immune fighting abilities, get through hard times and achieve a better quality of life, I’m-Yunity® for Dogs is an excellent choice!
Consult your veterinarian if your dog has had an organ transplant or is taking immunosuppressant medication.
The product is available at our international distributors, find in the "Distributors." For any query in payment and delivery, please contact us at email@example.com.
Suggested Use :
- For dogs, take 100mg/kg/day in two equal doses along with the morning and evening meals.
- Consult your veterinarian if your dog has had an organ transplant or is taking immunosuppressant medication.
Suitable individuals :
- Dogs need to boost their immune fighting abilities, get through hard times and achieve a better quality of life, I’m-Yunity® for Dogs is an excellent choice!
FAQ about I’m-Yunity®
Common queries and the answers for a better understanding of I’m-Yunity®.
A: There have been no reported true side effects using I’m-Yunity®. However, we recommend consulting with your veterinarian if your pet is on medications that suppress immune function or if your pet has an autoimmune disease. Since I’m-Yunity® is designed to support healthy immune function.
If your pet has a mushroom allergy then I’m-Yunity® may not be right for your pet too.
A: Currently, I’m-Yunity® has only been evaluated for safety and efficacy in dogs. Animal species other than dogs may react differently to I’m-Yunity®, so we cannot guarantee its safety and efficacy in all animal species. If there is not a medical reason why your animal cannot have a mushroom extract, then I’m-Yunity® would be considered reasonable to try for immune supplementation. We recommend discussing the use of I’m-Yunity® in any animal other than a dog with your veterinarian prior to use.
A: We have a study “In vivo effect of I’m-Yunity on hepatic cytochrome P450 3A4”, which investigated the ability of I’m-Yunity to inhibit or induce the drug metabolism of CYP3A4 in healthy adult human subjects. (The link to the abstract on Medline is here, if you need the full report please email us.) Some chemo drugs fall into this category. The results suggests that the administration of I’m-Yunity® with other medications and dietary supplements, which are primarily metabolized on this pathway, is not expected to be associated with significant herb-drug interactions. If you use any of the chemo drugs that are metabolized on this pathway, chances are you have a better safety profile using concomitantly.
As this study was done in human, it is difficult to say if the results would be the same in dogs without repeating a drug interaction study. However, in animal toxicity studies yunzhi was considered safe in doses up to 18g/kg in acute toxicity testing¹ and 6g/kg in a sub chronic toxicity testing².
A second clinical trial has begun and more detail about I’m-Yunity® with drugs or herbs will be learnt. If you are interested in joining second clinical trial, please click here.
A: I’m-Yunity® is definitely a premier product; many things go into creating and sourcing this quality product. Each batch of I’m-Yunity® is manufactured in cGMP facility and complies with heavy metal, microbial and pesticide testing requirements for each country it is imported to. In addition, we support continued research into I’m-Yunity® and other Chinese Medicine products, so that consumers can be assured of product efficacy and safety.
A direct way to reduce the average per capsule cost of I’m-Yunity® is to buy the value size, a bottle of 500 capsules can save you up to 30%. BUY Now
A: The animals in recently published clinical trial did not have problems swallowing the capsules directly. However, you can also mix the powder from the capsules with wet dog food. Make sure your animal has plenty of water to drink when taking I’m-Yunity®.
A: How long to give I’m-Yunity® to your pet is really up to you and depends on the benefits your pet receive from using the product. You can stay the product as an immune supplement similar to a vitamin. I’m-Yunity® supports general immune health and can be taken for long-term health benefits. Dogs taking I’m-Yunity® can enjoy a healthier lifestyle, supported by general fitness and a more robust immune function.
A: For I’m-Yunity® for Dogs, a recently published clinical trial shows that it works best in 100/mg per kilogram (kg) of bodyweight per day. That means the daily dose = dog’s weight (kg) X 100mg, splits in two equal doses taken with the morning and evening meals.
Please note this was a pilot study and the next study will provide more definitive results. The second clinical study has already begun, if you are interested in joining the second clinical trial, please
A: I’m-Yunity® is made from a unique proprietary ingredient extracted from Coriolus versicolor, which has long been recognized for its non-toxic and invigorating effects to preserve vitality. Traditionally, Chinese herbalists use it to relieve symptoms such as general weakness, fatigue, poor appetite and loose bowels. Modern herbalists use it as an immune modulator due to its strong immune promoting effects.
In general, the benefits of I’m-Yunity® can be seen within 7〜14 days. In animals this is largely down to the owner observing their pet’s behavior changes. If your pet is experiencing a good appetite, sufficient energy level, and quality sleep, this can be due to enhanced immune function and contributed to the use of I’m-Yunity®. As this product is designed to support healthy immune function; we would expect your pet to be healthy and remain healthy.
A: I’m-Yunity® comes in 400mg capsules with active ingredient – standardized polysaccharide peptide (PSP). Each capsule contains 38% or more of polysaccharide content and 11.5% or more of peptide content.
A: We only use the extract from the mycelia of COV-1® strain of Coriolus versicolor for I’m-Yunity®. It is a pure and single-species herbal supplement that doesn’t rely on other additional ingredients to exert its multiple health benefits. Our Company sources the proprietary extract from the inventor exclusively and supported mushroom research for over 20 years. The efficacy and safety of I’m-Yunity® are well researched in independent academic institutions in the U.S., Hong Kong and China.
We are also following up the study conducted in the well-known veterinary research center in the U.S. with a larger scale study to make sure the pilot results are repeatable with I’m-Yunity®, and there is direct benefit from Chinese medicine herbal products.
We value quality research and want to help people better understand about the products you choose to use.
A: I’m-Yunity® is made from Coriolus versicolor mushroom with active ingredient PSP (polysaccharide peptide), which is a safe herb that has been well documented in the Compendium of Materia Medica to enhance immune functions in both humans and animals. In animals, its results are largely down to the owner observing their pet’s behavior changes. If your pet is experiencing a good appetite, sufficient energy level, and quality sleep, this can be due to enhanced immune function and contributed to the use of I’m-Yunity® .
Study proven that dogs taking I’m-Yunity® enjoy a healthier lifestyle, supported by general fitness and a more robust immune function.